Smart Integrated Molecular Pathways

Helios Biosciences molecular interaction database contains a large and integrated intracellular signal transduction network.

All interactions are fully validated by referenced full text publications.


Our network is built in signal transduction logics.
It is suited for studies modeling the dynamics of biological systems.

Loops of signal transduction: basic units of the network.

Interconnection of all the units.

Integration of Protein AND Transcriptional cascades.

Each interaction is directed according to signal propagation direction.

Internal coherence of the network: exhaust of interactions between molecules already present before network extension.

Biological processes
General signal transduction
Apoptosis
Immune response (lymphocyte signal transduction)
Dozens of cancer genes
Interconnection with cell cycle and other biological functions (metabolism…)

To come:
Exhaustive cell cycle signal propagation
Exhaustive trophic factor signal propagation
Exhaustive cancer signal propagation

Current status
> 600 molecules / > 1900 interactions.
> 4 mean interactions / molecule.

> 100 kinases / phosphatases.
> 100 other signal transduction proteins.
> 100 transcription factors / cofactors.
> 50 ligand-receptor couples and downstream signal transduction cascades, interconnected and with feedback loops.

Entirely connected sub-network ≈ 400 molecules:
Signal propagation from any molecule to any other one.
> 5 mean interactions / molecule

Interactions: 95% Human / 4% Mouse / 1% Rat

Interaction information 
PMID describing the interaction 

Nature of signal propagation: chemical / mediated through second messenger / transcriptional / transport / enzymatic / physical 

Direction of interaction 

Effect of interaction (activation / inhibition) 

Species in which the interaction is described 

Additional information: cell compartment, physiological function… 

Unambiguous identification of molecules  

Signal propagation analyses 
All possible signal propagation pathways of any given length from any given molecule to any other one. 

Optimized calculation of most probable pathways indeed propagating the signals according to transcriptomics / proteomics data. 

Clear result visualization and analysis through easy-to-use filters. 

Results displayed through a friendly interactive interface.

Helios Molecular Interaction Database is the only one combining: Non-linear signal transduction / Direction of interactions / High connectivity