DynaPath

Helios Biosciences offers a new paradigm in systems biology: by introducing the dynamic dimension in the study of biological regulatory pathways, accurate therapeutic targets and bio-markers can be characterized using fast and cost-efficient techniques.

We build directed networks of intermolecular interactions and develop software to model their dynamic responses after pathological / pharmacological stimuli.

A dynamic model enables to reconstruct the variations of activity of the Molecular Interaction Cascade (MIC) elements during the assessment of a physiological situation. A physiological model is built on a given MIC to account for a given physiopathological situation. A mathematical function defined by Helios BioSciences is associated to each edge of the MIC. The dynamic model is obtained after a computing step that determines the numerical values of these mathematical function's parameters. It allows for large-scale systematic simulations which would otherwise be experimentally unattainable at such a scale. Such simulations aim at targeting molecules on which to act in order to reach a MIC predefined state, and thus correct the investigated physiopathological situation.